Eye photoreceptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Eye photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYN2, FCAR, and ZNF93, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye photoreceptor cell differentiation activity versus SYN2 in BRCA (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SYN2 →	+0.541	+0.414	.001	.003	3	5
PDAC	FCAR →	+0.524	+0.195	<.001	<.001	3	3
COAD	ZNF93 →	-0.699	-0.270	<.001	.001	3	3
UCEC	CRYAB →	+0.988	+0.677	<.001	<.001	3	2
UCEC	NR4A3 →	+0.796	+0.589	.003	.002	2	3
UCEC	ARHGAP24 →	+0.597	+0.733	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001754 vs SYN2 — BRCA

Explore this scatter interactively →