Eye photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Eye photoreceptor cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM1, RPL3L, and CYP4B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDM1 grouped by Eye photoreceptor cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRDM1 →	-0.333	-1.072	<.001	<.001	3	6
LUNG_NSCLC_LUAD	RPL3L →	-0.250	-0.932	.004	.005	3	5
KIDNEY	CYP4B1 →	-0.256	-0.856	.001	.006	3	5
LIVER	ALS2CL →	-0.191	-1.215	.002	.004	3	5
LARGE_INTESTINE	GRK2 →	-0.215	-1.101	.006	.002	3	5
SKIN	GUK1 →	-0.171	-0.991	.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDM1 by Eye photoreceptor cell differentiation activity — SKIN

Explore this box plot interactively →