Eye photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Eye photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM33, NFS1, and ZNF852, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM33 grouped by Eye photoreceptor cell differentiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM33 →	+0.888	+1.156	.002	.004	3	4
SKIN	NFS1 →	+0.564	+1.296	.008	<.001	3	4
LIVER	ZNF852 →	+0.813	+1.516	.001	<.001	3	4
STOMACH	SRSF2 →	-0.432	-1.398	.001	<.001	3	4
STOMACH	COL27A1 →	-2.760	-1.544	.001	<.001	3	4
BLOOD_Leukemia	PTOV1 →	-0.638	-0.954	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM33 by Eye photoreceptor cell differentiation activity — PANCREAS

Explore this box plot interactively →