Eye photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Eye photoreceptor cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED13, ARID3A, and ARL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED13 grouped by Eye photoreceptor cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MED13 →	-0.213	-0.303	.003	<.001	3	4
STOMACH	ARID3A →	-0.186	-0.334	.002	.003	3	4
LIVER	ARL6 →	-0.242	-0.407	.001	<.001	3	4
LUNG_NSCLC_LUSC	DLEU7 →	-0.346	-0.368	<.001	.006	3	3
LUNG_SCLC	DHX29 →	-0.240	-0.307	.001	.002	3	3
LUNG_SCLC	BMP6 →	-0.188	-0.264	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED13 by Eye photoreceptor cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →