Eye photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Eye photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF805, OARD1, and RAPGEF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye photoreceptor cell differentiation activity versus ZNF805 in URINARY_TRACT (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF805 →	+0.407	+0.265	.002	.002	3	4
PANCREAS	OARD1 →	-0.984	-0.305	.005	.001	2	5
CNS	RAPGEF2 →	+0.942	+0.208	<.001	.001	2	4
OESOPHAGUS	NAA16 →	-0.679	-0.353	<.001	.007	3	3
STOMACH	ZNF133 →	+1.003	+0.313	.003	.005	3	3
STOMACH	YBEY →	-1.808	-0.312	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001754 vs ZNF805 — URINARY_TRACT

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