Formation of cytoplasmic translation initiation complex

Across TCGA patient cohorts, RNA activity of the Formation of cytoplasmic translation initiation complex pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSPT1, NES, and RIOX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of cytoplasmic translation initiation complex activity versus GSPT1 in BRCA (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GSPT1 →	-0.355	-0.045	<.001	.002	3	5
BRCA	NES →	+0.508	+0.039	<.001	.003	3	5
BRCA	RIOX2 →	+0.375	+0.040	.002	.001	3	5
UCEC	RIPK1 →	-0.186	-0.090	<.001	<.001	3	5
CCRCC	SGCE →	+0.524	+0.054	.001	<.001	3	5
BRCA	UBE2G1 →	-0.201	-0.034	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001732 vs GSPT1 — BRCA

Explore this scatter interactively →