Formation of cytoplasmic translation initiation complex

Across TCGA patient cohorts, RNA activity of the Formation of cytoplasmic translation initiation complex pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHBDL2, LSM5, and RNF7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of cytoplasmic translation initiation complex activity versus RHBDL2 in LUAD (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RHBDL2 →	-0.700	-0.126	<.001	<.001	3	4
UCEC	LSM5 →	-0.656	-0.112	.003	<.001	3	3
UCEC	RNF7 →	-0.440	-0.075	.002	.003	3	3
UCEC	SLC2A1 →	-0.911	-0.099	.003	.002	3	3
UCEC	COL8A1 →	-1.315	-0.142	<.001	<.001	3	3
UCEC	ESM1 →	-0.880	-0.096	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001732 vs RHBDL2 — LUAD

Explore this scatter interactively →