Formation of cytoplasmic translation initiation complex

Across TCGA cell cohorts, RNA activity of the Formation of cytoplasmic translation initiation complex pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM12, H4C15, and POLR1H, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of cytoplasmic translation initiation complex activity versus LSM12 in PANCREAS (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LSM12 →	+1.125	+1.951	<.001	<.001	3	7
URINARY_TRACT	H4C15 →	-1.864	-2.394	.009	.002	3	6
OVARY	POLR1H →	+0.814	+1.760	.005	.002	3	6
LIVER	SRSF9 →	+0.670	+0.492	.003	<.001	3	5
PANCREAS	CCT4 →	+0.871	+1.381	<.001	.002	2	6
LIVER	PWP1 →	+0.570	+0.487	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001732 vs LSM12 — PANCREAS

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