Endodermal cell fate specification

Across TCGA patient cohorts, RNA activity of the Endodermal cell fate specification pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP4K1, SRP14, and TGM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell fate specification activity versus MAP4K1 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP4K1 →	+0.525	+0.084	<.001	<.001	3	4
LUAD	SRP14 →	-0.194	-0.059	.003	.008	3	3
BRCA	TGM2 →	+0.401	+0.104	<.001	<.001	3	3
LUAD	ZMYM2_T1376 →	-0.273	-0.053	.004	.003	3	3
LUAD	HLA-DRA →	+0.508	+0.055	<.001	.006	2	4
COAD	HNRNPU →	-0.210	-0.044	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001714 vs MAP4K1 — BRCA

Explore this scatter interactively →