Endodermal cell fate specification

Across TCGA patient cohorts, RNA activity of the Endodermal cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCOLCE, MEIS3, and TAGLN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell fate specification activity versus PCOLCE in BRCA (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCOLCE →	-1.216	-0.372	<.001	.008	3	6
BRCA	MEIS3 →	-1.478	-0.427	<.001	.001	3	5
BRCA	TAGLN →	-1.610	-0.477	<.001	<.001	3	5
BRCA	FSTL3 →	-1.202	-0.582	<.001	<.001	3	5
LSCC	LGALS1 →	-0.538	-0.280	.007	.005	3	5
LSCC	MARS2 →	+0.582	+0.241	.001	.008	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001714 vs PCOLCE — BRCA

Explore this scatter interactively →