Endodermal cell fate specification

Across TCGA cell cohorts, RNA activity of the Endodermal cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS2, NABP1, and TXNDC12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBMS2 grouped by Endodermal cell fate specification-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RBMS2 →	-1.024	-1.311	.001	.005	3	5
LUNG_NSCLC_LUAD	NABP1 →	-1.325	-0.858	<.001	<.001	3	4
OVARY	TXNDC12 →	-0.935	-1.095	.006	.001	3	4
SKIN	MEA1 →	-0.503	-0.672	.005	.005	3	4
SKIN	CSTB →	-0.827	-0.695	.008	.003	3	4
PANCREAS	DYNC1LI2 →	+0.708	+1.189	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBMS2 by Endodermal cell fate specification activity — STOMACH

Explore this box plot interactively →