Endodermal cell fate specification

Across TCGA cell cohorts, RNA activity of the Endodermal cell fate specification pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SREK1IP1, UGGT2, and PMPCA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SREK1IP1 grouped by Endodermal cell fate specification-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SREK1IP1 →	-0.400	-1.042	.009	.008	3	4
BLOOD_Leukemia	UGGT2 →	+0.235	+0.151	.009	.006	3	4
LUNG_NSCLC_LUSC	PMPCA →	+0.283	+1.641	<.001	.001	3	4
BONE	PKN2 →	-0.228	-2.342	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SPAG6 →	-0.090	-1.568	.003	<.001	3	4
LIVER	SGK2 →	+0.286	+2.299	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SREK1IP1 by Endodermal cell fate specification activity — LARGE_INTESTINE

Explore this box plot interactively →