Endodermal cell fate specification

Across TCGA cell cohorts, RNA activity of the Endodermal cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX2, STARD8, and FOSL1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell fate specification activity versus SOX2 in LUNG_SCLC (Pearson r = 0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SOX2 →	+5.187	+2.485	<.001	<.001	3	13
BLOOD_Leukemia	STARD8 →	-2.127	-0.253	<.001	<.001	3	10
BONE	FOSL1 →	-3.800	-1.387	<.001	<.001	3	10
SOFT_TISSUE	ABL2 →	-1.463	-1.715	<.001	<.001	3	9
LUNG_NSCLC_LUSC	RAB11FIP5 →	-1.605	-1.710	.001	<.001	3	9
LUNG_NSCLC_LUSC	MARCHF4 →	-2.636	-1.459	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001714 vs SOX2 — LUNG_SCLC

Explore this scatter interactively →