Endodermal cell fate commitment

Across TCGA patient cohorts, RNA activity of the Endodermal cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYO1G, STK10, and STAB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell fate commitment activity versus MYO1G in BRCA (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYO1G →	-0.487	-0.085	<.001	<.001	3	8
HNSC	STK10 →	-0.278	-0.081	<.001	<.001	3	7
PDAC	STAB1 →	-0.324	-0.086	<.001	<.001	3	7
BRCA	WIPF1 →	-0.353	-0.056	<.001	.001	3	7
HNSC	CASP4 →	-0.551	-0.090	<.001	<.001	3	7
COAD	FOLR2 →	-0.459	-0.035	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001711 vs MYO1G — BRCA

Explore this scatter interactively →