Endodermal cell fate commitment

Across TCGA cell cohorts, RNA activity of the Endodermal cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1, FLVCR1, and PRR3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell fate commitment activity versus HNRNPA1 in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HNRNPA1 →	+0.645	+1.084	<.001	<.001	3	9
BONE	FLVCR1 →	+0.795	+1.724	.005	<.001	3	9
BLOOD_Leukemia	PRR3 →	+0.907	+1.196	<.001	<.001	3	8
PANCREAS	TAF5 →	+0.812	+1.228	.002	.001	3	8
BREAST	ILF2 →	+0.746	+0.888	.002	.003	3	8
BLOOD_Leukemia	TADA1 →	+0.632	+1.127	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001711 vs HNRNPA1 — BREAST

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