Cell fate determination

Across TCGA patient cohorts, RNA activity of the Cell fate determination pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPTAN1, TJP1, and SEPTIN4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate determination activity versus SPTAN1 in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPTAN1 →	+0.411	+0.035	<.001	.005	3	8
CCRCC	TJP1 →	+0.322	+0.071	<.001	<.001	3	8
PDAC	SEPTIN4 →	+0.509	+0.030	<.001	<.001	3	7
UCEC	SPTBN1 →	+0.358	+0.084	<.001	.001	3	7
BRCA	ADD1 →	+0.432	+0.045	<.001	<.001	3	7
CCRCC	CD34 →	+0.780	+0.079	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001709 vs SPTAN1 — BRCA

Explore this scatter interactively →