Cell fate determination

Across TCGA patient cohorts, RNA activity of the Cell fate determination pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS9-AS2, LINC00924, and PDE1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate determination activity versus ADAMTS9-AS2 in LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADAMTS9-AS2 →	+0.774	+0.770	<.001	<.001	3	6
LUAD	LINC00924 →	+0.193	+0.777	<.001	<.001	3	6
BRCA	PDE1A →	+0.768	+0.839	.001	<.001	3	5
HNSC	ABCA8 →	+0.985	+0.603	<.001	.001	3	5
CCRCC	CDO1 →	+0.441	+0.623	<.001	<.001	3	5
CCRCC	EBF1 →	+0.732	+0.745	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001709 vs ADAMTS9-AS2 — LUAD

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