Cell fate determination

Across TCGA cell cohorts, RNA activity of the Cell fate determination pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRMPD2, MED27, and SPOP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRMPD2 grouped by Cell fate determination-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FRMPD2 →	+0.212	+1.113	.007	.001	3	4
BLOOD_Lymphoma	MED27 →	-0.799	-2.228	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SPOP →	-0.533	-0.804	.003	.001	3	4
LUNG_NSCLC_LUAD	PKN1 →	-0.727	-0.932	.009	.001	3	4
LUNG_NSCLC_LUAD	MEN1 →	-0.445	-0.736	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PSORS1C2 →	-0.863	-1.515	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRMPD2 by Cell fate determination activity — STOMACH

Explore this box plot interactively →