Cell fate determination

Across TCGA cell cohorts, RNA activity of the Cell fate determination pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAG1, HDDC3, and INO80B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate determination activity versus PRKAG1 in PANCREAS (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRKAG1 →	+0.818	+1.421	.002	.001	3	4
BONE	HDDC3 →	+1.483	+2.116	.009	<.001	3	4
BREAST	INO80B →	+0.900	+1.191	.003	.006	3	3
BREAST	RSL24D1 →	+0.803	+1.335	.004	.001	3	3
BREAST	SLC27A5 →	+1.458	+1.398	.004	<.001	3	3
KIDNEY	NMNAT3 →	-1.984	-1.506	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001709 vs PRKAG1 — PANCREAS

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