Cell fate specification

Across TCGA patient cohorts, RNA activity of the Cell fate specification pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNPY4, SPTAN1, and FARP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate specification activity versus CNPY4 in UCEC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNPY4 →	+0.453	+0.051	<.001	.001	3	7
PDAC	SPTAN1 →	+0.236	+0.030	<.001	<.001	3	7
UCEC	FARP1 →	+0.459	+0.052	<.001	<.001	3	7
PDAC	HDGFL3 →	+0.368	+0.037	<.001	<.001	3	7
UCEC	SPTBN1 →	+0.327	+0.055	<.001	<.001	3	6
BRCA	XRN1 →	-0.215	-0.027	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001708 vs CNPY4 — UCEC

Explore this scatter interactively →