Cell fate specification

Across TCGA cell cohorts, RNA activity of the Cell fate specification pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F2R, RP1, and ZNF646, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, F2R grouped by Cell fate specification-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F2R →	-0.193	-0.207	.003	.009	3	3
OVARY	RP1 →	+0.246	+1.244	.001	.007	3	3
CNS	ZNF646 →	+0.331	+0.205	.006	.009	3	3
BLOOD_Lymphoma	DCLRE1C →	-0.540	-0.398	.008	.003	3	2
OVARY	PI4KAP2 →	+0.282	+0.972	<.001	.003	3	2
STOMACH	LAMB2 →	+0.166	+0.513	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

F2R by Cell fate specification activity — CNS

Explore this box plot interactively →