Cell fate specification

Across TCGA cell cohorts, RNA activity of the Cell fate specification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS1, RPL10A, and GNB5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate specification activity versus IRS1 in LUNG_NSCLC_LUSC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IRS1 →	+2.752	+0.272	<.001	.001	3	3
LUNG_NSCLC_LUSC	RPL10A →	-0.756	-0.376	.006	.003	3	3
BLOOD_Lymphoma	GNB5 →	+0.866	+0.636	.007	.001	3	3
OVARY	FAM177A1 →	+0.736	+0.924	.002	<.001	3	3
BLOOD_Leukemia	MAST2 →	+0.735	+0.652	.003	.003	2	4
PANCREAS	MFSD4A →	-0.856	-0.271	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001708 vs IRS1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →