Endoderm formation

Across TCGA cell cohorts, RNA activity of the Endoderm formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFA5, HNRNPCL2, and ARID3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFA5 grouped by Endoderm formation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NDUFA5 →	+0.583	+0.123	.001	.003	3	4
PANCREAS	HNRNPCL2 →	-0.067	-0.252	.005	.001	3	4
BLOOD_Lymphoma	ARID3A →	-3.367	-0.410	.007	.002	3	4
BREAST	MTERF4 →	-0.823	-0.218	<.001	<.001	3	4
BLOOD_Lymphoma	ARHGEF11 →	-1.755	-0.429	.009	<.001	3	4
BLOOD_Lymphoma	GID4 →	+0.952	+0.403	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFA5 by Endoderm formation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →