Endoderm formation

Across TCGA cell cohorts, RNA activity of the Endoderm formation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP73, TLN1, and FRAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TP73 grouped by Endoderm formation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TP73 →	+0.195	+0.133	.003	.003	3	6
STOMACH	TLN1 →	+0.519	+0.130	<.001	.007	3	6
LUNG_SCLC	FRAT1 →	-0.338	-0.178	<.001	<.001	3	6
BREAST	CCDC47 →	-0.100	-0.134	.005	.004	3	6
LUNG_SCLC	CRKL →	+0.204	+0.142	.002	.001	3	5
STOMACH	ACLY →	-0.369	-0.127	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TP73 by Endoderm formation activity — BREAST

Explore this box plot interactively →