Endoderm formation

Across TCGA cell cohorts, RNA activity of the Endoderm formation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECHS1, DSE, and CALD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoderm formation activity versus ECHS1 in LIVER (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ECHS1 →	-0.592	-0.412	.001	<.001	3	5
CNS	DSE →	+1.709	+0.334	<.001	.001	2	6
CNS	CALD1 →	+1.743	+0.487	<.001	<.001	3	5
CNS	MRPL12 →	-0.724	-0.585	<.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	PCCB →	-1.083	-0.514	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	RASEF →	-1.155	-0.375	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001706 vs ECHS1 — LIVER

Explore this scatter interactively →