Formation of primary germ layer

Across TCGA patient cohorts, RNA activity of the Formation of primary germ layer pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULF1, CNN2, and COL3A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of primary germ layer activity versus SULF1 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SULF1 →	+1.053	+0.049	<.001	.001	3	10
GBM	CNN2 →	+0.611	+0.053	<.001	<.001	3	10
GBM	COL3A1 →	+0.970	+0.061	<.001	<.001	3	10
GBM	COL1A1 →	+0.982	+0.058	<.001	<.001	3	10
BRCA	COL5A1 →	+0.934	+0.031	<.001	<.001	3	10
GBM	SVIL →	+0.606	+0.076	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001704 vs SULF1 — GBM

Explore this scatter interactively →