Formation of primary germ layer

Across TCGA patient cohorts, RNA activity of the Formation of primary germ layer pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL1A2, SPARC, and FRMD6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of primary germ layer activity versus COL1A2 in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COL1A2 →	+1.142	+0.166	<.001	<.001	3	9
BRCA	SPARC →	+0.855	+0.145	.002	.004	3	8
LSCC	FRMD6 →	+0.894	+0.180	.002	.002	3	8
LUAD	COL3A1 →	+1.178	+0.176	<.001	<.001	3	8
OV	CAVIN1 →	+0.786	+0.116	<.001	<.001	3	7
OV	NUAK1 →	+0.885	+0.110	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001704 vs COL1A2 — LUAD

Explore this scatter interactively →