Gastrulation with mouth forming second

Across TCGA patient cohorts, RNA activity of the Gastrulation with mouth forming second pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP12, SH3BGRL2, and RPL5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gastrulation with mouth forming second activity versus PARP12 in HNSC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP12 →	-0.264	-0.066	<.001	<.001	3	8
HNSC	SH3BGRL2 →	+0.469	+0.074	<.001	.001	3	8
BRCA	RPL5 →	-0.205	-0.040	.001	<.001	3	7
PDAC	RNF213 →	-0.414	-0.062	<.001	<.001	3	7
HNSC	SETMAR →	+0.437	+0.072	<.001	.005	3	7
LSCC	BIN2 →	-0.435	-0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001702 vs PARP12 — HNSC

Explore this scatter interactively →