Gastrulation with mouth forming second

Across TCGA cell cohorts, RNA activity of the Gastrulation with mouth forming second pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1D, APLP1, and ARSB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPM1D grouped by Gastrulation with mouth forming second-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPM1D →	-0.459	-0.716	<.001	.008	3	4
LUNG_NSCLC_LUSC	APLP1 →	-2.436	-1.399	.008	.001	3	4
LUNG_NSCLC_LUSC	ARSB →	-1.066	-1.341	.002	<.001	3	4
URINARY_TRACT	HOXC8 →	+2.639	+1.897	<.001	<.001	3	3
BONE	NAGK →	-0.943	-1.554	.006	<.001	3	3
KIDNEY	AHCYL1 →	+0.792	+1.304	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPM1D by Gastrulation with mouth forming second activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →