tRNA 5'-leader removal

Across TCGA cell cohorts, RNA activity of the tRNA 5'-leader removal pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN23, ZNF783, and GOLGA8Q, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN23 grouped by tRNA 5'-leader removal-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTPN23 →	-0.668	-0.209	.001	.005	2	5
BONE	ZNF783 →	-1.196	-0.238	.001	.008	3	4
SOFT_TISSUE	GOLGA8Q →	-0.613	-0.296	.006	.003	2	5
BLOOD_Lymphoma	RABIF →	-0.555	-0.356	.004	.004	3	4
BLOOD_Myeloma	RAB5C →	-0.944	-0.280	<.001	.002	2	5
UPPER_AERODIGESTIVE_TRACT	SUSD3 →	+1.481	+0.249	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN23 by tRNA 5'-leader removal activity — BLOOD_Leukemia

Explore this box plot interactively →