tRNA 5'-leader removal

Across TCGA cell cohorts, RNA activity of the tRNA 5'-leader removal pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSB, CYSRT1, and SOCS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 5'-leader removal activity versus SSB in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SSB →	+0.541	+0.637	.006	.009	3	5
OVARY	CYSRT1 →	-1.259	-1.129	.003	<.001	3	5
SOFT_TISSUE	SOCS2 →	+3.524	+1.159	.001	.004	2	6
UPPER_AERODIGESTIVE_TRACT	RPL7 →	+1.049	+1.220	.001	<.001	3	5
LARGE_INTESTINE	TENT5B →	-0.814	-0.667	.008	.009	3	5
BLOOD_Myeloma	ANKRD46 →	+1.225	+1.206	.003	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001682 vs SSB — BLOOD_Leukemia

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