Intracellular glucose homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular glucose homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL13A1, AP3S1, and SLC9A6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL13A1 grouped by Intracellular glucose homeostasis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COL13A1 →	-2.219	-0.234	<.001	.002	3	5
SOFT_TISSUE	AP3S1 →	-0.541	-0.178	.006	.009	3	4
SOFT_TISSUE	SLC9A6 →	-0.507	-0.231	.004	<.001	3	4
BLOOD_Lymphoma	ZNF770 →	+0.621	+0.183	.003	.002	2	5
LUNG_SCLC	ZNF182 →	+0.887	+0.218	.005	.003	3	4
LUNG_SCLC	EIF3C →	-1.127	-0.277	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL13A1 by Intracellular glucose homeostasis activity — SKIN

Explore this box plot interactively →