Intracellular glucose homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular glucose homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THOP1, PCK2, and VTA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular glucose homeostasis activity versus THOP1 in PANCREAS (Pearson r = -0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	THOP1 →	-1.083	-0.316	<.001	<.001	3	6
PANCREAS	PCK2 →	+1.639	+0.245	.001	.002	3	6
BONE	VTA1 →	-0.777	-0.187	.001	.008	3	6
URINARY_TRACT	GPX1 →	+1.650	+0.326	.006	.005	3	5
PANCREAS	SMC2 →	-1.023	-0.181	.006	.009	2	6
BONE	NOSIP →	-1.156	-0.236	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001678 vs THOP1 — PANCREAS

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