Long-chain fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSR, TRIM28, and TTC39A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid metabolic process activity versus GSR in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSR →	+0.524	+0.053	<.001	.002	3	7
GBM	TRIM28 →	-0.264	-0.034	<.001	<.001	3	6
LUAD	TTC39A →	+0.687	+0.032	<.001	.001	3	6
GBM	CAPNS1 →	+0.214	+0.037	<.001	<.001	3	6
LUAD	FYCO1 →	+0.278	+0.032	<.001	<.001	3	6
BRCA	ARHGEF37_S251 →	+0.864	+0.024	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001676 vs GSR — UCEC

Explore this scatter interactively →