Long-chain fatty acid metabolic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPT1P9, FTLP3, and PLA2G4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid metabolic process activity versus TPT1P9 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPT1P9 →	+1.366	+0.202	.001	<.001	3	5
BRCA	FTLP3 →	+1.179	+0.233	.001	.001	3	5
LSCC	PLA2G4A →	+1.225	+0.209	<.001	<.001	3	4
OV	GPM6A →	-0.672	-0.110	.008	.007	3	4
OV	CD3E →	+0.818	+0.137	.007	.005	3	4
OV	IGLV6-57 →	+2.967	+0.208	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001676 vs TPT1P9 — UCEC

Explore this scatter interactively →