Acrosome assembly

Across TCGA patient cohorts, RNA activity of the Acrosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLINT1, MTCL1_S1514, and CLIP2_S42, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosome assembly activity versus CLINT1 in LSCC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLINT1 →	-0.124	-0.034	.002	.001	3	6
PDAC	MTCL1_S1514 →	+0.656	+0.036	<.001	.004	3	5
OV	CLIP2_S42 →	+0.887	+0.042	<.001	.002	3	4
OV	CRTAP →	+0.663	+0.035	<.001	.002	3	4
BRCA	FADS1 →	+0.701	+0.046	.006	.002	3	4
UCEC	GNL1 →	+0.170	+0.055	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001675 vs CLINT1 — LSCC

Explore this scatter interactively →