Acrosome assembly

Across TCGA patient cohorts, RNA activity of the Acrosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSAT1P3, BSPRY, and ADCY3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosome assembly activity versus PSAT1P3 in COAD (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSAT1P3 →	+0.188	+0.639	<.001	<.001	3	3
LUAD	BSPRY →	-0.445	-0.391	.006	.007	3	3
PDAC	ADCY3 →	-0.227	-0.549	.003	.006	3	3
OV	EXTL2P1 →	+0.319	+0.793	.001	<.001	3	3
OV	GAPDHP62 →	-0.236	-0.786	<.001	<.001	3	3
LSCC	H2BC11 →	-0.696	-0.577	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001675 vs PSAT1P3 — COAD

Explore this scatter interactively →