Acrosome assembly

Across TCGA cell cohorts, RNA activity of the Acrosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IP6K2, NPHP4, and ZNF852, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosome assembly activity versus IP6K2 in PANCREAS (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IP6K2 →	+1.064	+1.189	.004	.003	3	4
LIVER	NPHP4 →	+2.486	+1.803	<.001	<.001	3	4
LIVER	ZNF852 →	+1.156	+1.383	.005	.006	3	4
OVARY	DCP1A →	+0.918	+1.218	<.001	.001	3	4
PANCREAS	DVL2 →	+1.011	+1.297	<.001	.001	3	4
OVARY	ANXA3 →	-4.617	-0.998	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001675 vs IP6K2 — PANCREAS

Explore this scatter interactively →