Temperature homeostasis

Across TCGA patient cohorts, RNA activity of the Temperature homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRAP, TNFAIP8L2, and SPN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Temperature homeostasis activity versus GRAP in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GRAP →	+0.370	+0.038	.002	<.001	3	7
GBM	TNFAIP8L2 →	+0.455	+0.035	<.001	<.001	3	7
GBM	SPN →	+0.713	+0.060	<.001	<.001	3	7
OV	SRRM2_T1531 →	-0.922	-0.028	.003	.001	3	7
GBM	MNDA →	+1.277	+0.060	<.001	<.001	3	6
OV	BST1 →	+0.815	+0.029	.007	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001659 vs GRAP — LSCC

Explore this scatter interactively →