Temperature homeostasis

Across TCGA patient cohorts, RNA activity of the Temperature homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G_S42, HDAC1_S421, and JPH2_S534, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Temperature homeostasis activity versus EIF3G_S42 in OV (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EIF3G_S42 →	-0.672	-0.173	<.001	<.001	3	3
OV	HDAC1_S421 →	+1.436	+0.214	.001	<.001	3	3
LUAD	JPH2_S534 →	-1.391	-0.366	<.001	<.001	3	3
PDAC	BRAT1 →	+0.264	+0.144	<.001	<.001	3	2
OV	CCNYL1_S344 →	+0.722	+0.214	<.001	<.001	3	2
COAD	CEP250 →	-0.591	-0.330	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001659 vs EIF3G_S42 — OV

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