Temperature homeostasis

Across TCGA cell cohorts, RNA activity of the Temperature homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM10, EXOSC2, and MIOS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Temperature homeostasis activity versus PRDM10 in BREAST (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRDM10 →	-0.454	-0.262	.007	.001	3	5
SKIN	EXOSC2 →	-0.762	-0.328	<.001	<.001	3	4
BLOOD_Lymphoma	MIOS →	-0.644	-0.180	.001	<.001	3	4
LUNG_NSCLC_LUSC	PELO →	+1.158	+0.333	.009	.003	3	4
BONE	SEH1L →	-1.197	-0.280	.001	.002	3	4
PANCREAS	ELP1 →	-0.731	-0.187	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001659 vs PRDM10 — BREAST

Explore this scatter interactively →