Metanephros development

Across TCGA patient cohorts, RNA activity of the Metanephros development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOCS2, ZEB1, and LAYN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephros development activity versus SOCS2 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOCS2 →	+1.027	+0.841	.005	.001	3	5
LUAD	ZEB1 →	+0.593	+0.811	<.001	<.001	3	5
COAD	LAYN →	+0.654	+0.161	<.001	<.001	3	5
COAD	SPARC →	+0.801	+0.162	.007	<.001	1	6
UCEC	GASK1B →	+0.916	+0.504	.005	.006	3	4
COAD	PMP22 →	+0.557	+0.176	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001656 vs SOCS2 — GBM

Explore this scatter interactively →