Metanephros development

Across TCGA cell cohorts, RNA activity of the Metanephros development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD10, TATDN3, and PACSIN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD10 grouped by Metanephros development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MFSD10 →	-1.316	-1.486	.004	<.001	3	4
BONE	TATDN3 →	+0.881	+1.441	.004	.002	2	5
LIVER	PACSIN3 →	-0.787	-1.173	.003	.002	3	3
LIVER	SMARCA2 →	-1.775	-1.482	.009	.008	3	3
LUNG_NSCLC_LUAD	DTNB →	-0.857	-0.767	<.001	.001	3	3
SKIN	NBEAL1 →	+0.377	+0.716	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD10 by Metanephros development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →