Metanephros development

Across TCGA cell cohorts, RNA activity of the Metanephros development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAZALD1, BASP1, and NR3C1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephros development activity versus KAZALD1 in SOFT_TISSUE (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KAZALD1 →	-2.796	-0.358	<.001	.003	3	6
LUNG_NSCLC_LUSC	BASP1 →	+5.045	+0.373	.003	.005	3	5
STOMACH	NR3C1 →	+2.920	+0.314	<.001	<.001	3	5
BLOOD_Lymphoma	ABHD4 →	+1.267	+0.373	.001	.001	3	5
LUNG_NSCLC_LUSC	CDKN2AIP →	-0.751	-0.304	.001	.009	3	4
LARGE_INTESTINE	ZHX2 →	-0.967	-0.168	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001656 vs KAZALD1 — SOFT_TISSUE

Explore this scatter interactively →