Urogenital system development

Across TCGA patient cohorts, RNA activity of the Urogenital system development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISG20, DOK3, and TYMP_S50, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urogenital system development activity versus ISG20 in HNSC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ISG20 →	-0.448	-0.038	.003	.006	2	8
GBM	DOK3 →	-0.456	-0.044	.001	<.001	3	7
UCEC	TYMP_S50 →	-1.036	-0.120	.004	.003	3	6
GBM	MLKL →	-0.460	-0.040	.001	.001	3	6
UCEC	SEPTIN11 →	+0.264	+0.041	.001	.002	3	6
LUAD	ARHGAP25_S512 →	-0.354	-0.032	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001655 vs ISG20 — HNSC

Explore this scatter interactively →