Urogenital system development

Across TCGA patient cohorts, RNA activity of the Urogenital system development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, SEPTIN2, and SERPINF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urogenital system development activity versus VCAN in HNSC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VCAN →	+0.907	+0.423	<.001	.002	2	6
UCEC	SEPTIN2 →	+0.295	+0.244	<.001	<.001	3	4
BRCA	SERPINF1 →	+0.759	+0.130	<.001	<.001	3	4
BRCA	SRPX2 →	+0.902	+0.180	<.001	<.001	3	4
BRCA	SSC5D →	+0.726	+0.139	<.001	<.001	3	4
CCRCC	SULF1 →	+0.858	+0.124	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001655 vs VCAN — HNSC

Explore this scatter interactively →