Urogenital system development

Across TCGA cell cohorts, RNA activity of the Urogenital system development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PET100, JPH1, and VPS35, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PET100 grouped by Urogenital system development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PET100 →	-0.682	-1.364	.003	<.001	3	4
SOFT_TISSUE	JPH1 →	-1.547	-1.317	.007	.001	3	4
SOFT_TISSUE	VPS35 →	+0.838	+1.266	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	BRF2 →	-0.732	-0.917	<.001	.002	3	4
SOFT_TISSUE	LDHD →	+0.830	+1.234	.004	<.001	3	3
BLOOD_Lymphoma	SIRT6 →	+0.736	+1.651	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PET100 by Urogenital system development activity — SOFT_TISSUE

Explore this box plot interactively →