Osteoblast differentiation

Across TCGA patient cohorts, RNA activity of the Osteoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN_S2116, PCOLCE, and POSTN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast differentiation activity versus VCAN_S2116 in PDAC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VCAN_S2116 →	+1.034	+0.027	<.001	<.001	3	10
OV	PCOLCE →	+0.752	+0.034	<.001	<.001	3	10
HNSC	POSTN →	+1.206	+0.066	<.001	<.001	3	10
LUAD	RCN3 →	+0.625	+0.030	<.001	<.001	3	9
OV	SERPINH1 →	+0.664	+0.044	<.001	<.001	3	9
BRCA	THBS2 →	+1.367	+0.032	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001649 vs VCAN_S2116 — PDAC

Explore this scatter interactively →