Osteoblast differentiation

Across TCGA patient cohorts, RNA activity of the Osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1G, ANKRD6, and PTPN14, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast differentiation activity versus POLR1G in COAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	POLR1G →	+0.543	+0.188	<.001	<.001	3	2
COAD	ANKRD6 →	+0.515	+0.163	.003	.001	3	2
COAD	PTPN14 →	+0.727	+0.124	.004	.007	3	2
COAD	SUGCT →	+0.627	+0.118	<.001	<.001	3	2
BRCA	VWDE →	+1.619	+0.290	<.001	.003	3	2
BRCA	LINC01693 →	+0.132	+0.290	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001649 vs POLR1G — COAD

Explore this scatter interactively →