Osteoblast differentiation

Across TCGA patient cohorts, RNA activity of the Osteoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCN1, RGS14_S478, and RIPOR1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Osteoblast differentiation activity versus CCN1 in COAD (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CCN1 →	+1.170	+0.225	<.001	<.001	3	2
COAD	RGS14_S478 →	+0.498	+0.332	.001	<.001	3	1
COAD	RIPOR1 →	+0.283	+0.124	<.001	<.001	3	1
COAD	RNF169_S247 →	+0.337	+0.201	<.001	<.001	3	1
COAD	ASAP3_S862 →	+0.728	+0.178	<.001	<.001	3	1
COAD	S100A9_T113 →	+0.780	+0.133	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001649 vs CCN1 — COAD

Explore this scatter interactively →